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ea0049ep537 | Diabetes complications | ECE2017

PDE5i preserves renal function in models of Diabetic Nephropathy: from bench to bedside

Pofi Riccardo , Fiore Daniela , Feola Tiziana , Giannetta Elisa , Grazie Giulia Le , Dato Carla Di , Gianfrilli Daniele , Barbano Biagio , Venneri Mary A. , Lenzi Andrea , Isidori Andrea M.

One third of diabetic patients suffer from Diabetic Nephropathy (DN) that leads to end-stage renal disease (ESRD). The molecular pathways involved remain underexplored. We showed that chronic phosphodiesterase-5 inhibition (PDE5i) improve vascular inflammation [1] and tissue remodelling, reducing proteinuria [2] in murine diabetes. Our aim was to investigate the effect of PDE5i on animal and human models of DN.Materials and methods: 16 mice were randomly...

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ea0056gp35 | Adrenal cortex | ECE2018

The circadian rhythm of glucocorticoid administration entrains clock-controlled genes in blood mononuclear cells: a DREAM trial ancillary study

Venneri Mary Anna , Hasenmajer Valeria , Fiore Daniela , Sbardella Emilia , Pofi Riccardo , Graziadio Chiara , Gianfrilli Daniele , Pivonello Claudia , Negri Mariarosaria , Naro Fabio , Grossman Ashley B , Lenzi Andrea , Pivonello Rosario , Isidori Andrea M

Introduction: Adrenal insufficiency requires life-long glucocorticoid replacement. Conventional therapies fail to mimic endogenous cortisol circadian rhythm. Clock genes are essential components of the molecular machinery controlling organs circadian function and are influenced by glucocorticoids. However, clock genes expression has never been investigated in patients with adrenal insufficiency (AI).Aim: To evaluate the effect of the timing of gluc...

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Endocrine Abstracts

PDE5i preserves renal function in models of Diabetic Nephropathy: from bench to bedside

The circadian rhythm of glucocorticoid administration entrains clock-controlled genes in blood mononuclear cells: a DREAM trial ancillary study

BiosciAbstracts